Journal article
Enhanced immunogenicity of BCG vaccine by using a viral-based GM-CSF transgene adjuvant formulation
Abstract
The failure of current BCG vaccine in controlling the global tuberculosis (TB) epidemic highlights an urgent need for improved TB vaccine formulations. In this study, we have investigated the effect of a novel adenoviral granulocyte macrophage-colony stimulating factor (GM-CSF) transgene-based adjuvant formulation (AdGM-CSF) on BCG vaccination in a mouse strain that is genetically weak responders to BCG vaccine. BALB/c mice were immunized …
Authors
Wang J; Zganiacz A; Xing Z
Journal
Vaccine, Vol. 20, No. 23-24, pp. 2887–2898
Publisher
Elsevier
Publication Date
July 2002
DOI
10.1016/s0264-410x(02)00241-4
ISSN
0264-410X