Journal article
The Antimicrobial/Elastase Inhibitor Elafin Regulates Lung Dendritic Cells and Adaptive Immunity
Abstract
Infections with bacteria and viruses such as adenovirus are a feature of chronic lung diseases such as chronic obstructive pulmonary diseases (COPD), and may be instrumental in the generation of disease exacerbations. We have previously shown in acute models that elafin (a lung natural chemotactic molecule for macrophages and neutrophils, with potent antimicrobial and neutrophil elastase inhibitor activity) is upregulated in infection and …
Authors
Roghanian A; Williams SE; Sheldrake TA; Brown TI; Oberheim K; Xing Z; Howie SEM; Sallenave J-M
Journal
American Journal of Respiratory Cell and Molecular Biology, Vol. 34, No. 5, pp. 634–642
Publisher
American Thoracic Society
Publication Date
May 2006
DOI
10.1165/rcmb.2005-0405oc
ISSN
1044-1549
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdenoviridaeAnimalsAntibodies, ViralBronchoalveolar Lavage FluidCD11c AntigenCell ProliferationCytokinesDendritic CellsGene ExpressionHumansImmunityLeukocyte ElastaseLungMiceMice, Inbred C57BLMyeloid CellsNeutralization TestsProteinase Inhibitory Proteins, SecretoryProteinsSpleenVaccinationVaccines, DNA