γ‐aminobutyric acid nurtures allergic asthma Journal Articles

abstract

• SummaryAsthma often occurs as a result of immune‐based inflammatory responses, which consequently cause pathological changes in airway structural cells. However, the underlying mechanisms of airway pathology in asthma are still not fully understood. Our recent studies revealed a critical role of γ‐aminobutyric acid (GABA) signalling pathway in the airway epithelium of allergic asthma through its ability to stimulate mucus production. This review briefly describes the GABAergic signalling system and its role in the regulation of mucus protein production in bronchial airway epithelial cells.

authors

• Lu, W‐Y
• Inman, Mark David

status

• published 

publication date

• July 2009

has subject area

• 1107 Immunology (FoR)
• 1111 Nutrition and Dietetics (FoR)
• 1117 Public Health and Health Services (FoR)
• Allergy (Science Metrix)
• Animals (MeSH)
• Asthma (MeSH)
• Bronchi (MeSH)
• Epithelial Cells (MeSH)
• Humans (MeSH)
• Models, Immunological (MeSH)
• Mucus (MeSH)
• Signal Transduction (MeSH)
• gamma-Aminobutyric Acid (MeSH)

published in

• Clinical and Experimental Allergy  Journal

keywords

• Animals
• Asthma
• Bronchi
• Epithelial Cells
• Humans
• Models, Immunological
• Mucus
• Signal Transduction
• gamma-Aminobutyric Acid

Digital Object Identifier (DOI)

• 10.1111/j.1365-2222.2009.03265.x

PubMed ID

• 19400904

start page

• 956

end page

• 961

volume

• 39

issue

• 7