Journal article
Isoprostanes constrict human radial artery by stimulation of thromboxane receptors, Ca2+ release, and RhoA activation
Abstract
OBJECTIVES: Radial artery vasospasm remains a potential cause of early graft failure after coronary bypass graft surgery, despite pretreatment with alpha-adrenergic or calcium channel blockers. We examined the roles of isoprostanes and prostanoid receptors selective for thromboxane A2 in the vasoconstriction of human radial arteries.
METHODS: Human radial arterial segments were pretreated intraoperatively with verapamil/papaverine or …
Authors
Mueed I; Tazzeo T; Liu C; Pertens E; Zhang Y; Cybulski I; Semelhago L; Noora J; Lamy A; Teoh K
Journal
Journal of Thoracic and Cardiovascular Surgery, Vol. 135, No. 1, pp. 131–138
Publisher
Elsevier
Publication Date
January 2008
DOI
10.1016/j.jtcvs.2007.06.023
ISSN
0022-5223