Journal article
Oral Budesonide for Active Crohn's Disease
Abstract
BACKGROUND: Corticosteroids are the most efficacious drugs for inducing remission in active Crohn's disease, but their benefits are frequently offset by serious side effects. Budesonide is a corticosteroid with high topical antiinflammatory activity but low systemic activity because of extensive hepatic metabolism. We investigated the efficacy and safety of an oral controlled-ileal-release preparation of budesonide in patients with active …
Authors
Greenberg GR; Feagan BG; Martin F; Sutherland LR; Thomson A; Williams CN; Nilsson L-G; Persson T
Journal
The New England Journal of Medicine, Vol. 331, No. 13, pp. 836–841
Publisher
Massachusetts Medical Society
Publication Date
September 29, 1994
DOI
10.1056/nejm199409293311303
ISSN
0028-4793