Impact of p16 expression, nodal status, and smoking on oncologic outcomes of patients with head and neck unknown primary squamous cell carcinoma.
Journal Articles
Overview
Research
Identity
Additional Document Info
View All
Overview
abstract
BACKGROUND: The prognostic significance of human papillomavirus (HPV) in the context of head and neck squamous cell carcinoma (HNSCC) of cancer of unknown primary (CUP) origin is unclear. METHODS: Patients treated for CUP at the Princess Margaret Cancer Centre between 2001 and 2013 were stratified by p16 status and retrospectively reviewed. RESULTS: Of the 73 patients included, those with p16-positive tumors (63%) had less advanced nodal status (N1-N2b; 52% vs 89%; p = .035) and less aggressive treatment. Patients with p16-positive tumors had improved 3-year disease-free survival (DFS; 79% vs 56%; p = .012) independent of nodal status and treatment in multivariable analysis (hazard ratio [HR] = 0.27; 95% confidence interval [CI] = 0.08-0.95). CONCLUSION: Among patients with CUP, p16-positive status is an independent predictor of DFS but not overall survival (OS). © 2016 Wiley Periodicals, Inc. Head Neck, 2016 © 2016 Wiley Periodicals, Inc. Head Neck 38: 1347-1353, 2016.
status
publication date
has subject area
published in
Research
keywords
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
Cancer Care Facilities
Carcinoma, Squamous Cell
Cyclin-Dependent Kinase Inhibitor p16
Female
Head and Neck Neoplasms
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Neoplasms, Unknown Primary
Ontario
Papillomaviridae
Predictive Value of Tests
Prognosis
Proportional Hazards Models
Registries
Retrospective Studies
Risk Assessment
Smoking
Squamous Cell Carcinoma of Head and Neck
Survival Analysis
head and neck neoplasms
human papilloma virus
p16
squamous cell carcinoma
unknown primary neoplasms
Identity
Digital Object Identifier (DOI)
PubMed ID
Additional Document Info
start page
end page
volume
issue