Autocatalytic Symmetry Breaking and Chiral Amplification in a Feedback Network Combining Amino Acid Synthesis and Ligation. Journal Articles uri icon

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abstract

  • A kinetic model coupling prebiotically plausible synthesis of enantioenriched proteinogenic amino acids with catalytic peptide ligation leads to an autocatalytic network that may exhibit symmetry breaking and chiral amplification, providing a feasible route to the emergence of biological homochirality. We show that symmetry breaking leading to chiral amplification can occur in two ways: a constructive mechanism in which dimers catalyze the synthesis of monomers of the same enantiomer, and a destructive mechanism in which dimers catalyze the breakdown of monomers of the opposite enantiomer.

publication date

  • May 20, 2025