Journal article
EXTH-51. ENHANCING GLIOBLASTOMA TREATMENT: ALLOGENEIC CAR-T CELLS OVERCOMES FUNCTIONAL DEFICITS OF PATIENT-DERIVED AUTOLOGOUS PRODUCTS
Abstract
Abstract Glioblastoma (GBM) is the most common primary brain malignancy in adults, with a dismal prognosis despite an intensive standard of care. Recently, chimeric antigen receptor T-cell (CAR-T) therapy has shown promising outcomes in treating liquid malignancies. However, clinical trials targeting various tumor antigens in GBM failed to show durable clinical benefit. Though this may stem from various tumor-intrinsic immune evasion strategies …
Authors
Shaikh MV; Salim SK; Maich WT; Ananad A; Wei J; Subapanditha MK; Suk Y; Singh M; Tabunshchyk Z; Chen K
Journal
Neuro-Oncology, Vol. 26, No. Supplement_8, pp. viii248–viii248
Publisher
Oxford University Press (OUP)
Publication Date
November 11, 2024
DOI
10.1093/neuonc/noae165.0982
ISSN
1522-8517