Journal article
Inhibiting Mitochondrial Complex II Exposes a Novel Metabolic Vulnerability in Acute Myeloid Leukemia
Abstract
Abstract
Acute myeloid leukemia (AML) is a hematological malignancy, characterized by an increased reliance on mitochondria-related energetic pathways including oxidative phosphorylation (OXPHOS). Consistent with this, the electron transport chain (ETC), a component of OXPHOS has been demonstrated to be a suitable anti-leukemia target, with ETC complex I inhibitors currently in clinical development. Relative to its …
Authors
Roma A; Tcheng M; Ahmed N; Walker S; Jayanth P; Minden MD; Hope K; Rao PPN; Luc J; Doxey AC
Journal
Blood, Vol. 138, No. Supplement 1,
Publisher
American Society of Hematology
Publication Date
November 5, 2021
DOI
10.1182/blood-2021-148708
ISSN
0006-4971