Journal article
Effectiveness and risk of ARB and ACEi among different ethnic groups in England: A reference trial (ONTARGET) emulation analysis using UK Clinical Practice Research Datalink Aurum-linked data
Abstract
BACKGROUND: Guidelines by the National Institute for Health and Care Excellence recommend an angiotensin receptor blocker (ARB) rather than an angiotensin-converting enzyme inhibitor (ACEi) for the treatment of hypertension for people of African and Caribbean descent, due to an increased risk of angioedema associated with ACEi use observed in US trials. However, the effectiveness and risk of these drugs in Black populations in UK routine care …
Authors
Baptiste PJ; Wong AYS; Schultze A; Clase CM; Leyrat C; Williamson E; Powell E; Mann JFE; Cunnington M; Teo K
Journal
PLOS Medicine, Vol. 21, No. 9,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pmed.1004465
ISSN
1549-1277