Journal article
Spatial Fold Change of FGF Signaling Encodes Positional Information for Segmental Determination in Zebrafish
Abstract
Signal gradients encode instructive information for numerous decision-making processes during embryonic development. A striking example of precise, scalable tissue-level patterning is the segmentation of somites-the precursors of the vertebral column-during which the fibroblast growth factor (FGF), Wnt, and retinoic acid (RA) pathways establish spatial gradients. Despite decades of studies proposing roles for all three pathways, the dynamic …
Authors
Simsek MF; Özbudak EM
Journal
Cell Reports, Vol. 24, No. 1, pp. 66–78.e8
Publisher
Elsevier
Publication Date
July 2018
DOI
10.1016/j.celrep.2018.06.023
ISSN
2639-1856