Journal article
Sceliphrolactam, a Polyene Macrocyclic Lactam from a Wasp-Associated Streptomyces sp.
Abstract
A previously unreported 26-membered polyene macrocyclic lactam, sceliphrolactam, was isolated from an actinomycete, Streptomyces sp., associated with the mud dauber, Sceliphron caementarium. Sceliphrolactam's structure was determined by 1D- and 2D-NMR, MS, UV, and IR spectral analysis. Sceliphrolactam displays antifungal activity against amphotericin B-resistant Candida albicans (MIC = 4 μg/mL, 8.3 μM).
Authors
Oh D-C; Poulsen M; Currie CR; Clardy J
Journal
Organic Letters, Vol. 13, No. 4, pp. 752–755
Publisher
American Chemical Society (ACS)
Publication Date
February 18, 2011
DOI
10.1021/ol102991d
ISSN
1523-7060