Reversal of hypertrophic osteoarthropathy after chemotherapy for bronchogenic carcinoma. Journal Articles uri icon

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abstract

  • A patient with hypertrophic osteoarthropathy (HO) secondary to large cell anaplastic carcinoma of the lung was treated with combination chemotherapy (CAP-1). Systemic tumor symptoms resolved within 3 wk. Relief from the bone and articular symptoms of HO was noted after 3 months of treatment, coincident with a partial remission (greater than 50% tumor regression). Objective improvement in the radionuclide bone scan and radiographic periostitis was demonstrated after 6 months. Symptomatic improvement continued despite evidence of tumor progression after 10 months of treatment. Systemic chemotherapy should be considered in the management of symptomatic osteoarthropathy secondary to unresectable bronchogenic carcinoma.

publication date

  • 1980