Preprint
Cardiorenal effects of dual blockade with Angiotensin-converting enzyme inhibitors and Angiotensin receptor blockers in people with CKD: analysis of routinely collected data with emulation of a reference trial (ONTARGET)
Abstract
Abstract We aimed to explore whether the ONTARGET trial results, which led to an end of recommendations of dual angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blocker (ARB) use, extended to patients with chronic kidney disease (CKD) who were underrepresented in the trial. We selected people prescribed an ACEi and/or an ARB in the UK Clinical Practice Research Datalink Aurum during 1/1/2001-31/7/2019. We specified an …
Authors
Baptiste PJ; Wong AY; Schultze A; Clase CM; Leyrat C; Williamson E; Powell E; Mann JF; Cunnington M; Teo K
DOI
10.1101/2024.05.28.24307859
Preprint server
medRxiv