Dose-Dependent Development of Depressive Symptoms During Adjuvant Interferon-  Treatment of Patients With Malignant Melanoma Journal Articles uri icon

  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All


  • BACKGROUND: Adjuvant IFN-α treatment for patients with malignant melanoma is often complicated by depression. The influence of dosage, however, is unknown. OBJECTIVE: The authors sought to elucidate this dosage effect. METHOD: Using the Zung Self-Rating Depression Scale and the German Bf-S Self-Rating (Affectivity) Scale, the authors prospectively compared the frequency and severity of IFN-α-induced depressive symptoms between a group of 29 patients receiving low-dose and 17 patients getting high-dose induction therapy for 4 weeks. RESULTS: Patients receiving high-dose induction treatment had significantly higher depression scores after 4 weeks, and significantly more patients in the high-dose group developed depression. CONCLUSION: The authors concluded that frequency and severity of IFN-α-associated depression during melanoma treatment are dose-dependent.


  • Friebe, A
  • Horn, M
  • Schmidt, F
  • Janssen, G
  • Schmid-Wendtner, M-H
  • Volkenandt, M
  • Hauschild, A
  • Goldsmith, Charles Harry
  • Schaefer, M

publication date

  • November 1, 2010