Novel 5-HT7 receptor antagonists modulate intestinal immune responses and reduce severity of colitis Journal Articles uri icon

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abstract

  • This study demonstrates that the novel highly selective 5-HT7 receptor antagonists, MC-170073 and MC-230078, significantly alleviated the severity of colitis across models of experimental colitis. These findings suggest that inhibition of 5-HT7 receptor signaling by these new antagonists may serve as an alternative mode of treatment to diminish symptomology in those with inflammatory bowel disease.

authors

  • Kwon, Yun Han
  • Blass, Benjamin E
  • Wang, Huaqing
  • Grondin, Jensine A
  • Banskota, Suhrid
  • Korzekwa, Kenneth
  • Ye, Min
  • Gordon, John C
  • Colussi, Dennis
  • Blattner, Kevin M
  • Canney, Daniel J
  • Khan, Waliul

publication date

  • July 1, 2024