Journal article
Novel 5-HT7 receptor antagonists modulate intestinal immune responses and reduce severity of colitis
Abstract
Inflammatory bowel disease (IBD) encompasses several debilitating chronic gastrointestinal (GI) inflammatory disorders, including Crohn's disease and ulcerative colitis. In both conditions, mucosal inflammation is a key clinical presentation associated with altered serotonin (5-hydroxytryptamine or 5-HT) signaling. This altered 5-HT signaling is also found across various animal models of colitis. Of the 14 known receptor subtypes, 5-HT receptor …
Authors
Kwon YH; Blass BE; Wang H; Grondin JA; Banskota S; Korzekwa K; Ye M; Gordon JC; Colussi D; Blattner KM
Journal
AJP Gastrointestinal and Liver Physiology, Vol. 327, No. 1, pp. g57–g69
Publisher
American Physiological Society
Publication Date
July 1, 2024
DOI
10.1152/ajpgi.00299.2023
ISSN
0193-1857