Preprint
Nutrient Sensing Receptor GPRC6A Regulates mTORC1 Signaling and Tau Biology
Abstract
Abstract Tauopathies, including Alzheimer’s disease (AD), comprise microtubule-associated protein tau aggregates that cause neuronal cell death and clinical cognitive decline. Reducing overall tau abundance remains a central strategy for therapeutics; however, no disease-modifying treatment exists to date. One principal pathway for balancing cellular proteostasis includes the mechanistic target of rapamycin complex 1 (mTORC1) signaling. …
Authors
Ma C; Campbell K; Kovalenko A; Sandusky-Beltran LA; Liang H; Hunt JB; Calahatian J; Kallupurackal M; Pandey S; Vasisht M
DOI
10.1101/2024.03.24.586459
Preprint server
bioRxiv