Journal article
89Zr-labeled ImmunoPET targeting the cancer stem cell antigen CD133 using fully-human antibody constructs
Abstract
BackgroundCancer stem cells play an important role in driving tumor growth and treatment resistance, which makes them a promising therapeutic target to prevent cancer recurrence. Emerging cancer stem cell-targeted therapies would benefit from companion diagnostic imaging probes to aid in patient selection and monitoring response to therapy. To this end, zirconium-89-radiolabeled immunoPET probes that target the cancer stem cell-antigen CD133 …
Authors
Wyszatko K; Janzen N; Silva LR; Kwon L; Komal T; Ventura M; Venugopal C; Singh SK; Valliant JF; Sadeghi S
Journal
EJNMMI Research, Vol. 14, No. 1,
Publisher
Springer Nature
DOI
10.1186/s13550-024-01091-9
ISSN
2191-219X