Journal article
A189 INVESTIGATING THE ROLE OF BACTERIAL HISTAMINE METABOLISM IN VISCERAL HYPERALGESIA
Abstract
AbstractBackground
Intestinal microbiota have been implicated in the expression of irritable bowel syndrome (IBS) as patients present with altered gut microbial profiles and microbial metabolic activity. We have previously identified bacterial histamine to strongly influence mast cell accumulation through only IBS activation of the H4 receptor, leading to visceral hyperalgesia in a subset of patients with IBS. We hypothesize that a subset of IBS …
Authors
Ross T; Pujo J; Hall-Bruce M; Collins S; Vanner S; Reed DE; Bercik P; De Palma G
Journal
Journal of the Canadian Association of Gastroenterology, Vol. 7, No. Supplement_1, pp. 148–149
Publisher
Oxford University Press (OUP)
Publication Date
February 14, 2024
DOI
10.1093/jcag/gwad061.189
ISSN
2515-2084