Journal article
Investigating the Role of 17-Beta Estradiol in the Regulation of the Unfolded Protein Response (UPR) in Pancreatic Beta Cells
Abstract
Diabetes mellitus is clinically defined by chronic hyperglycemia. Sex differences in the presentation and outcome of diabetes exist with premenopausal women having a reduced risk of developing diabetes, relative to men, or women after menopause. Accumulating evidence shows a protective role of estrogens, specifically 17-beta estradiol, in the maintenance of pancreatic beta cell health; however, the mechanisms underlying this protection are …
Authors
De Paoli M; Shah D; Zakharia A; Patel Z; Patel Z; Pakhi P; Werstuck GH
Journal
International Journal of Molecular Sciences, Vol. 25, No. 3,
Publisher
MDPI
DOI
10.3390/ijms25031816
ISSN
1661-6596