Journal article
Association of plasma biomarkers with cognition, cognitive decline, and daily function across and within neurodegenerative diseases: Results from the Ontario Neurodegenerative Disease Research Initiative
Abstract
INTRODUCTION: We investigated whether novel plasma biomarkers are associated with cognition, cognitive decline, and functional independence in activities of daily living across and within neurodegenerative diseases.
METHODS: Glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), phosphorylated tau (p-tau)181 and amyloid beta (Aβ)42/40 were measured using ultra-sensitive Simoa immunoassays in 44 healthy controls and 480 …
Authors
Sanchez E; Wilkinson T; Coughlan G; Mirza S; Baril A; Ramirez J; Binns MA; Black SE; Borrie M; Dilliott AA
Journal
Alzheimer's & Dementia, Vol. 20, No. 3, pp. 1753–1770
Publisher
Wiley
Publication Date
March 2024
DOI
10.1002/alz.13560
ISSN
1552-5260