Journal article
The Interaction between Amyloid-β Peptides and Anionic Lipid Membranes Containing Cholesterol and Melatonin
Abstract
One of the hallmarks of Alzheimer's disease is the formation of senile plaques, primarily consisting of amyloid-β (Aβ) peptides. Peptide-membrane and peptide-lipid interactions are thought to be crucial in this process. We studied the interaction of Aβ₁₋₄₂ and Aβ₂₅₋₃₅ peptides with anionic lipid membranes made of dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphoserine (DMPS) using X-ray diffraction. We compare the experimentally …
Authors
Dies H; Toppozini L; Rheinstädter MC
Journal
PLOS ONE, Vol. 9, No. 6,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pone.0099124
ISSN
1932-6203