Journal article
Liver Metastases and Immune Checkpoint Inhibitor Efficacy in Patients With Refractory Metastatic Colorectal Cancer
Abstract
Importance: Immune checkpoint inhibitors (ICIs) have limited activity in microsatellite-stable (MSS) or mismatch repair-proficient (pMMR) colorectal cancer. Recent findings suggest the efficacy of ICIs may be modulated by the presence of liver metastases (LM).
Objective: To investigate the association between the presence of LM and ICI activity in advanced MSS colorectal cancer.
Authors
Chen EX; Loree JM; Titmuss E; Jonker DJ; Kennecke HF; Berry S; Couture F; Ahmad CE; Goffin JR; Kavan P
Journal
JAMA Network Open, Vol. 6, No. 12,
Publisher
American Medical Association (AMA)
Publication Date
December 1, 2023
DOI
10.1001/jamanetworkopen.2023.46094
ISSN
2574-3805