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Genome-wide association study meta-analysis of...
Journal article

Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity

Abstract

STUDY QUESTION: Which genetic factors regulate female propensity for giving birth to spontaneous dizygotic (DZ) twins? SUMMARY ANSWER: We identified four new loci, GNRH1, FSHR, ZFPM1, and IPO8, in addition to previously identified loci, FSHB and SMAD3.

Authors

Mbarek H; Gordon SD; Duffy DL; Hubers N; Mortlock S; Beck JJ; Hottenga J-J; Pool R; Dolan CV; Actkins KV

Journal

Human Reproduction, Vol. 39, No. 1, pp. 240–257

Publisher

Oxford University Press (OUP)

Publication Date

January 5, 2024

DOI

10.1093/humrep/dead247

ISSN

0268-1161