Sex-differences in resting-state brain activity in children with concussion in comparison to matched healthy controls.

There are known sex-differences with respect to the clinical presentation of pediatric concussion, with girls reporting more symptoms and symptoms with greater severity than boys. This is the first study to show that there are also sex-differences in resting state brain activity in children with concussion, suggesting that the sex-specific clinical presentation may have neurological underpinnings. Specifically, girls with concussion had resting state disturbances that were not present in boys, which is consistent with the variable symptom presentation of the injury. Continued research into these resting state differences is encouraged.