Journal article
Regulatory mechanism of hypothalamo-pituitary–adrenal (HPA) axis and neuronal changes after adrenalectomy in type 2 diabetes
Abstract
Diabetes, especially type 2, is closely associated with hypothalamo-pituitary-adrenal (HPA) axis regulation. Short-term effects of adrenalectomy (ADX) in type 2 diabetes are well characterized; however, there have been few reports on the long-term effects of ADX in genetically engineered type 2 diabetes and the neuroendocrine system. We performed bilateral ADX in Zucker Lean Control rats (ZLC; ADX-ZLC), Zucker Diabetic Fatty rats (ZDF; …
Authors
Yi SS; Hwang IK; Shin JH; Choi JH; Lee CH; Kim IY; Kim YN; Won M-H; Park I-S; Seong JK
Journal
Journal of Chemical Neuroanatomy, Vol. 40, No. 2, pp. 130–139
Publisher
Elsevier
Publication Date
October 2010
DOI
10.1016/j.jchemneu.2010.05.003
ISSN
0891-0618
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdrenalectomyAnalysis of VarianceAnimalsArginine VasopressinBlood GlucoseBlotting, WesternCorticosteroneCorticotropin-Releasing HormoneDiabetes Mellitus, Type 2FemaleGlucose Tolerance TestHypothalamo-Hypophyseal SystemHypothalamusImmunohistochemistryMaleNeuronsPituitary GlandPituitary-Adrenal SystemRadioimmunoassayRatsRats, ZuckerReceptors, GlucocorticoidReverse Transcriptase Polymerase Chain Reaction