Journal article
Garcinia buchananii stem bark extract and its bioactive constituents manniflavanone, GB-2 and buchananiflavanone attenuate intestinal inhibitory neuromuscular transmission
Abstract
Garcinia buchananii stem bark extract (GBB), commonly used for treating diarrhea in Africa, triggers ectopic aboral contractions, causing inhibition of propulsive motility in the colon ex vivo. To determine whether or not these effects were associated with decreased inhibitory neuromuscular transmission, the responsible constituent compounds, and mechanisms of action, we studied the effects of GBB and specific fractions and flavanones isolated …
Authors
Patterson S; Waters ME; Braman N; Willson R; Hill RA; Magolan J; Hofmann T; Stark TD; Balemba OB
Journal
Journal of Smooth Muscle Research, Vol. 59, No. 0, pp. 34–57
Publisher
Japan Society of Smooth Muscle Research
Publication Date
2023
DOI
10.1540/jsmr.59.34
ISSN
0916-8737