Preprint
Differential Effects of Chronic Immunosuppression on Behavioral, Epigenetic and Alzheimer’s Disease-Associated Markers in 3xtg-AD Mice
Abstract
Background: Circulating autoantibodies and sex-dependent discrepancy in prevalence are unexplained phenomena of Alzheimer’s disease (AD). Using the 3xTg-AD mouse model, we reported that adult males show early manifestations of systemic autoimmunity, increased emotional reactivity, enhanced expression of the histone variant macroH2A1 in the cerebral cortex, and loss of plaque/tangle pathology. Conversely, adult females display less severe …
Authors
Kapadia M; Mian FM; Ma D; Hutton CP; Azam A; Narkaj K; Cao C; Brown B; Michalski B; Morgan D
DOI
10.21203/rs.3.rs-60074/v2
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