Journal article
Abstract 2648: Prognostic significance of thyroid hormone receptor-alpha-2 (THRα2) expression in triple-negative breast cancer: A TCGA study
Abstract
Abstract
Background: Thyroid hormones promote breast cancer cell proliferation and expression of their cognate nuclear receptors has shown prognostic potential in small cohort studies. Among two isoforms of thyroid hormone receptor alpha (THRα), the alpha1 splice variant (THRα1) promotes thyroid hormone mediated cell proliferation whereas the alpha2 variant (THRα2) opposes it. Hence, THRα2 expression may be a favorable …
Authors
Jerzak KJ; Dvorkin-Gheva A; Cockburn JG; Bane A; Hassell JA
Journal
Cancer Research, Vol. 78, No. 13_Supplement, pp. 2648–2648
Publisher
American Association for Cancer Research (AACR)
Publication Date
July 1, 2018
DOI
10.1158/1538-7445.am2018-2648
ISSN
0008-5472