A263 IBS-D MICROBIOTA INDUCES GUT-BRAIN DYSFUNCTION BY DISRUPTING INTESTINAL NEURAL AND IMMUNE PATHWAYS

Irritable Bowel Syndrome (IBS) is a disorder of the gut-brain axis, with altered gut function and frequent psychiatric co-morbidity. We have previously shown in gnotobiotic mice that fecal microbiota from patients with IBS with diarrhea (IBS-D) and co-morbid anxiety induces faster gastrointestinal transit, gut barrier dysfunction, immune activation and anxiety-like behavior. However, the exact mechanisms underlying these abnormalities are not …