The endoplasmic reticulum stress inhibitor, 4‐phenylbutyrate, attenuates chronic kidney disease induced by a model of cardiorenal syndrome (1136.12)

Endoplasmic reticulum stress has been identified as a feature of chronic kidney disease and appears to be associated with proteinuria. We have found the endoplasmic reticulum stress inhibitor, 4‐phenylbutyrate (4‐PBA), reduced renal damage in a mouse model of acute kidney injury. Therefore, we hypothesized that inhibition of endoplasmic reticulum stress through augmenting protein folding with a low molecular weight chemical chaperone, 4‐PBA, …