Journal article
Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease
Abstract
The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry genome-wide association studies we identify 61 (58 previously unreported) loci for the spatial QRS-T angle (N = 118,780) and 11 for the frontal QRS-T angle (N = 159,715). Seven out of the 61 spatial QRS-T angle loci have …
Authors
Young WJ; Haessler J; Benjamins J-W; Repetto L; Yao J; Isaacs A; Harper AR; Ramirez J; Garnier S; van Duijvenboden S
Journal
Nature Communications, Vol. 14, No. 1,
Publisher
Springer Nature
DOI
10.1038/s41467-023-36997-w
ISSN
2041-1723