Chapter
Neurotrophins and Cell Death
Abstract
Early in development, the nervous system overproduces neurons and synapses. Throughout development, this initial surplus of cells is reduced and the connections between them refined via tightly controlled cell death. Cell death is regulated by a family of secreted proteins known as the neurotrophins. The four members of this family, nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 …
Authors
Shekari A; Mahadeo C; Sanwalka N; Fahnestock M
Book title
Neurodevelopmental Pediatrics
Pagination
pp. 55-75
Publisher
Springer Nature
Publication Date
2023
DOI
10.1007/978-3-031-20792-1_4