Gas chromatography mass spectrometry of some steroidal spirolactones

Abstract Gas chromatography mass spectrometry of a number of steroidal spirolactones and their TMS ethers is reported. Open tubular column gas chromatography provides useful structural information for these compounds as shown by shifts in retention index values. The electron impact fragmentation pathways have been established for a number of the compounds. The results of the study indicate that open tubular column gas chromatography mass spectrometry will be of value in studies of the metabolism of this class of steroids in animals and man.