Journal article
Intranasal multivalent adenoviral-vectored vaccine protects against replicating and dormant M.tb in conventional and humanized mice
Abstract
Viral-vectored vaccines are highly amenable for respiratory mucosal delivery as a means of inducing much-needed mucosal immunity at the point of pathogen entry. Unfortunately, current monovalent viral-vectored tuberculosis (TB) vaccine candidates have failed to demonstrate satisfactory clinical protective efficacy. As such, there is a need to develop next-generation viral-vectored TB vaccine strategies which incorporate both vaccine antigen …
Authors
Afkhami S; D’Agostino MR; Vaseghi-Shanjani M; Lepard M; Yang JX; Lai R; Choi MWY; Chacon A; Zganiacz A; Franken KLMC
Journal
npj Vaccines, Vol. 8, No. 1,
Publisher
Springer Nature
DOI
10.1038/s41541-023-00623-z
ISSN
2059-0105