Journal article
Polyomavirus-Plasmid Recombinants Capable of Replicating Have an Enhanced Transforming Potential
Abstract
The frequency of transformation of rodent fibroblasts by polyomavirus is enhanced by a viral gene product, large T-antigen. However, this effect of large T-antigen cannot be demonstrated with pBR322-cloned viral DNA. Recently, it was discovered that pBR322 contains cis-acting sequences inhibitory to DNA replication in mammalian cells. Because polyomavirus large T-antigen is required for viral DNA replication, we examined the possibility that …
Authors
Muller WJ; Naujokas MA; Hassell JA
Journal
Molecular and Cellular Biology, Vol. 3, No. 9, pp. 1670–1674
Publisher
Taylor & Francis
Publication Date
September 1, 1983
DOI
10.1128/mcb.3.9.1670-1674.1983
ISSN
0270-7306