Journal article
Activation of the WT1 tumor suppressor gene promoter by Pea3
Abstract
Gene array profiling of RNA from cells engineered to express a dominant-negative version of the ETS family member transcription factor Pea3 (polyomavirus enhancer activator 3) identified WT1 as a candidate downstream gene. Given the co-expression of WT1 and Pea3 in developing kidney and breast tissue undergoing mesenchymal to epithelial transitions, we further characterized this potential gene hierarchy. Analysis of the human WT1 promoter …
Authors
Discenza MT; Vaz D; Hassell JA; Pelletier J
Journal
FEBS Letters, Vol. 560, No. 1-3, pp. 183–191
Publisher
Wiley
Publication Date
February 27, 2004
DOI
10.1016/s0014-5793(04)00104-8
ISSN
0014-5793
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdenoviridaeAnimalsBase SequenceBinding SitesBlotting, WesternBreast NeoplasmsCHO CellsCOS CellsCell Line, TumorChlorocebus aethiopsCricetinaeCricetulusGene Expression Regulation, NeoplasticGenes, Wilms TumorHumansOligonucleotide Array Sequence AnalysisPromoter Regions, GeneticSequence DeletionTranscription FactorsTranscriptional ActivationTransfectionWT1 ProteinsWilms Tumor