Journal article
Amyloid-PET of the white matter: Relationship to free water, fiber integrity, and cognition in patients with dementia and small vessel disease
Abstract
White matter (WM) injury is frequently observed along with dementia. Positron emission tomography with amyloid-ligands (Aβ-PET) recently gained interest for detecting WM injury. Yet, little is understood about the origin of the altered Aβ-PET signal in WM regions. Here, we investigated the relative contributions of diffusion MRI-based microstructural alterations, including free water and tissue-specific properties, to Aβ-PET in WM and to …
Authors
Ottoy J; Ozzoude M; Zukotynski K; Kang MS; Adamo S; Scott C; Ramirez J; Swardfager W; Lam B; Bhan A
Journal
Cerebrovascular and Brain Metabolism Reviews, Vol. 43, No. 6, pp. 921–936
Publisher
SAGE Publications
Publication Date
June 2023
DOI
10.1177/0271678x231152001
ISSN
1040-8827