Journal article
Modified intention-to-treat analysis did not bias trial results
Abstract
OBJECTIVE: To investigate whether analysis of the modified intention-to-treat (mITT) population with postrandomization exclusion of patients from analysis is associated with biased estimates of treatment effect compared to the conservative intention-to-treat (ITT) population.
STUDY DESIGN AND SETTING: Placebo-controlled, blinded randomized trials on biological or targeted interventions for rheumatoid arthritis were identified through a …
Authors
Dossing A; Tarp S; Furst DE; Gluud C; Wells GA; Beyene J; Hansen BB; Bliddal H; Christensen R
Journal
Journal of Clinical Epidemiology, Vol. 72, , pp. 66–74
Publisher
Elsevier
Publication Date
April 2016
DOI
10.1016/j.jclinepi.2015.11.003
ISSN
0895-4356