Journal article
Direct Near-infrared Luminescence Detection of Singlet Oxygen Generated by Photodynamic Therapy in Cells In Vitro and Tissues In Vivo
Abstract
Singlet oxygen (1O2) is believed to be the major cytotoxic agent involved in photodynamic therapy (PDT). Measurement of 1O2 near-infrared (NIR) luminescence at 1270 nm in biological environments is confounded by the strongly reduced 1O2 lifetime and probably has never been achieved. We present evidence that this is now possible, using a new NIR-sensitive photomultiplier tube. Time-resolved 1O2 luminescence measurements were made in various …
Authors
Niedre M; Patterson MS; Wilson BC
Journal
Photochemistry and Photobiology, Vol. 75, No. 4, pp. 382–391
Publication Date
April 1, 2002
DOI
10.1562/0031-8655(2002)075<0382:dnildo>2.0.co;2
ISSN
0031-8655