Journal article
Age-Dependent Synthesis of Diverse Autoantibodies in the 3xTg-AD Model of Alzheimer’s Disease
Abstract
Abstract Elevated levels of serum autoantibodies are a well-documented phenomenon in patients with Alzheimer’s disease (AD), but the nature of the autoimmunity is unclear. Triple-transgenic (3xTg-AD) mice are a well-established model that develops AD-like pathology. We observed that recent cohorts of male 3xTg-AD mice exhibit autoimmune manifestations, yet lack plaque/tangle pathology. In the current study, we identified the time course and …
Authors
Ma D; Song W; Kapadia M; Fahnestock M; Sakic B
Journal
The Journal of Immunology, Vol. 204, No. 1_Supplement, pp. 64.5–64.5
Publisher
Oxford University Press (OUP)
Publication Date
May 1, 2020
DOI
10.4049/jimmunol.204.supp.64.5
ISSN
0022-1767