Journal article
Development of an inhaled anti-TSLP therapy for asthma
Abstract
Thymic stromal lymphopoietin (TSLP), an epithelial cell-derived cytokine, acts as a key mediator in airway inflammation and modulates the function of multiple cell types, including dendritic cells and group 2 innate lymphoid cells. TSLP plays a role in asthma pathogenesis as an upstream cytokine, and data suggest that TSLP blockade with the anti-TSLP monoclonal antibody, tezepelumab, could be efficacious in a broad asthma population. Currently …
Authors
O'Byrne PM; Panettieri RA; Taube C; Brindicci C; Fleming M; Altman P
Journal
Pulmonary Pharmacology & Therapeutics, Vol. 78, ,
Publisher
Elsevier
Publication Date
February 2023
DOI
10.1016/j.pupt.2022.102184
ISSN
1094-5539