Journal article
PCSK9 facilitates melanoma pathogenesis via a network regulating tumor immunity
Abstract
BackgroundPCSK9 regulates cholesterol homeostasis and promotes tumorigenesis. However, the relevance of these two actions and the mechanisms underlying PCSK9’s oncogenic roles in melanoma and other cancers remain unclear.MethodsPCSK9’s association with melanoma was analysed using the TCGA dataset. Empty vector (EV), PCSK9, gain-of-function (D374Y), and loss-of-function (Q152H) PCSK9 mutant were stably-expressed in murine melanoma B16 cells and …
Authors
Gu Y; Lin X; Dong Y; Wood G; Seidah NG; Werstuck G; Major P; Bonert M; Kapoor A; Tang D
Journal
Journal of Experimental & Clinical Cancer Research, Vol. 42, No. 1,
Publisher
Springer Nature
DOI
10.1186/s13046-022-02584-y
ISSN
0392-9078