Journal article
Statistical power and validity of Ebola vaccine trials in Sierra Leone: a simulation study of trial design and analysis
Abstract
BACKGROUND: Safe and effective vaccines could help to end the ongoing Ebola virus disease epidemic in parts of west Africa, and mitigate future outbreaks of the virus. We assess the statistical validity and power of randomised controlled trial (RCT) and stepped-wedge cluster trial (SWCT) designs in Sierra Leone, where the incidence of Ebola virus disease is spatiotemporally heterogeneous, and is decreasing rapidly.
METHODS: We projected …
Authors
Bellan SE; Pulliam JRC; Pearson CAB; Champredon D; Fox SJ; Skrip L; Galvani AP; Gambhir M; Lopman BA; Porco TC
Journal
The Lancet Infectious Diseases, Vol. 15, No. 6, pp. 703–710
Publisher
Elsevier
Publication Date
June 2015
DOI
10.1016/s1473-3099(15)70139-8
ISSN
1473-3099