Journal article
Elevated SOCS3 and altered IL-6 signaling is associated with age-related human muscle stem cell dysfunction
Abstract
Aging is associated with increased circulating interleukin-6 (IL-6) and a reduced myogenic capacity, marked by reduced muscle stem cell [satellite cell (SC)] activity. Although IL-6 is important for normal SC function, it is unclear whether elevated IL-6 associated with aging alters SC function. We hypothesized that mild chronically elevated IL-6 would be associated with a blunted SC response through altered IL-6 signaling and elevated …
Authors
McKay BR; Ogborn DI; Baker JM; Toth KG; Tarnopolsky MA; Parise G
Journal
American Journal of Physiology - Cell Physiology, Vol. 304, No. 8, pp. c717–c728
Publisher
American Physiological Society
Publication Date
April 15, 2013
DOI
10.1152/ajpcell.00305.2012
ISSN
0363-6143