Selective apoptosis-inducing activity of crinum-type Amaryllidaceae alkaloids Journal Articles uri icon

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  • The selective apoptosis-inducing activity of Amaryllidaceae alkaloids belonging to the crinane-type is reported. A mini-library of natural and synthetic crinane alkaloids was assembled. Biological screening indicated crinamine 4 and haemanthamine 9 to be potent inducers of apoptosis in tumour cells at micromolar concentrations. Structure-activity relationships demonstrated the requirement for both an alpha-C2 bridge and a free hydroxyl at the C-11 position as pharmacophoric requirements for this activity.


  • Mcnulty, James
  • Nair, Jerald J
  • Codina, Carles
  • Bastida, Jaume
  • Pandey, Siyaram
  • Gerasimoff, Jenny
  • Griffin, Carly

publication date

  • April 2007