Journal article
Selective apoptosis-inducing activity of crinum-type Amaryllidaceae alkaloids
Abstract
The selective apoptosis-inducing activity of Amaryllidaceae alkaloids belonging to the crinane-type is reported. A mini-library of natural and synthetic crinane alkaloids was assembled. Biological screening indicated crinamine 4 and haemanthamine 9 to be potent inducers of apoptosis in tumour cells at micromolar concentrations. Structure-activity relationships demonstrated the requirement for both an alpha-C2 bridge and a free hydroxyl at the …
Authors
McNulty J; Nair JJ; Codina C; Bastida J; Pandey S; Gerasimoff J; Griffin C
Journal
Phytochemistry, Vol. 68, No. 7, pp. 1068–1074
Publisher
Elsevier
Publication Date
April 2007
DOI
10.1016/j.phytochem.2007.01.006
ISSN
0031-9422