Conference
Abstract A24: Identifying the genomic and clinical features of AKT1/PIK3CA mutant metastatic prostate cancer using circulating tumor DNA
Abstract
Abstract
Background: Hotspot activating mutations in AKT1 and PIK3CA represent a rare but potentially unique subset of metastatic prostate cancers (mPCa). The accompanying genomic and clinical features of these patients are currently unknown. Preclinical evidence suggests that unconstrained PI3K signaling via PTEN loss may render androgen receptor (AR)-targeted therapy less effective. Given the availability of agents that …
Authors
Herberts CM; Murtha AJ; Fu S; Wang G; Schönlau E; Gleave A; Yip S; Angeles A; Hotte S; Alshangiti A
Volume
26
Pagination
pp. a24-a24
Publisher
American Association for Cancer Research (AACR)
Publication Date
June 1, 2020
DOI
10.1158/1557-3265.liqbiop20-a24
Conference proceedings
Clinical Cancer Research
Issue
11_Supplement
ISSN
1078-0432