Journal article
Estimation of 4-Butoxyphenylacetohydroxamic Acid Utilizing the Lossen Rearrangement
Abstract
A sensitive and specific GLC method for the determination of 4-butoxyphenylacetohydroxamic acid (bufexamac) is described. The trimethylsilyl derivative of bufexamac is chromatographed with docosane as the internal standard. This derivative of bufexamac undergoes the Lossen rearrangement on the column to give a quantitative yield of 4-butoxybenzylisocyanate. Possible metabolites of the drug, 4-butoxyphenylacetic acid and 4-butoxyphenylacetamide, …
Authors
Dell D; Boreham DR; Martin BK
Journal
Journal of Pharmaceutical Sciences, Vol. 60, No. 9, pp. 1368–1370
Publisher
Elsevier
Publication Date
September 1971
DOI
10.1002/jps.2600600917
ISSN
1520-6017