Journal article
The metabolism of canrenone in vitro by rat liver preparations
Abstract
1. The metabolism of [1-3H]canrenone, a primary metabolite of spironolactone and potassium canrenoate, by rat liver preparations in vitro has been investigated. 2. Canrenone was metabolized by 3-oxo-delta 4-reduction to give 3 alpha-hydroxy-5 beta-spirolactones, and also by a number of O2 and NADPH-dependent microsomal hydroxylation reactions. 3. A major metabolic route requiring the presence of a microsomal fraction, but apparently independent …
Authors
Boreham DR; Vose CW; Palmer RF; Slater TF; Cheeseman K
Journal
Xenobiotica, Vol. 11, No. 4, pp. 231–240
Publisher
Taylor & Francis
Publication Date
January 1981
DOI
10.3109/00498258109045297
ISSN
0049-8254