Journal article
Automated synthesis of [18F]DCFPyL via direct radiofluorination and validation in preclinical prostate cancer models
Abstract
BackgroundProstate-specific membrane antigen (PSMA) is frequently overexpressed and upregulated in prostate cancer. To date, various 18F- and 68Ga-labeled urea-based radiotracers for PET imaging of PSMA have been developed and entered clinical trials. Here, we describe an automated synthesis of [18F]DCFPyL via direct radiofluorination and validation in preclinical models of prostate cancer.Methods[18F]DCFPyL was synthesized via direct …
Authors
Bouvet V; Wuest M; Jans H-S; Janzen N; Genady AR; Valliant JF; Benard F; Wuest F
Journal
EJNMMI Research, Vol. 6, No. 1,
Publisher
Springer Nature
Publication Date
12 2016
DOI
10.1186/s13550-016-0195-6
ISSN
2191-219X